Endocrine Abstracts

Background: Despite its desirable half-life and high-energy Auger electrons, 67Ga has been neglected as a therapeutic Auger electron emitter, due in part to lack of suitable chelators and targeting molecules.Objective: Here, 67Ga is compared with Auger electron emitter 111In as a therapeutic radionuclide in prostate cancer and breast cancer cell lines.Method: Plasmid pBR322 studies allowed direct co...

Ga-68 labelled urea-based inhibitors of the prostate specific membrane antigen (PSMA), such as 68Ga-HBED-PSMA-11, are promising peptides for targeting prostate cancer. The tris(hydroxypyridinone) (THP) ligand rapidly complexes 68Ga3+ at room temperature, at very low concentration and over a wide pH range, making it possible for the direct elution from a 68Ge/68Ga generator into a cold radiopharmaceutical kit in one step wi...